Immobilized HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer, His & Avi, Human, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 9.5 ng/ml determined by ELISA.

The purity of HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer, His & Avi, Human on Bis-Tris PAGE under Non reducing (N) condition. The purity is greater than 95%.

HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer, His & Avi, Human

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target.

产品编号	Z06595
规格	100 μg 500 μg 大单询价
数量
价格	￥9900


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产品简介

Species

Human

Protein Construction

HLA-A02:01&B2M&Survivin (LMLGEFLKL) Tetramer[Gly25-Thr305(HLA-A02:01), Ile21-Met119(B2M) and LMLGEFLKL peptide] Accession # A0A140T913(HLA-A*02:01)&P61769(B2M)&LMLGEFLKL	His	Avi
N-term		C-term

Purity

> 95% as determined by BisTris PAGE
> 95% as determined by HPLC

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Measured by its binding ability in a functional ELISA. Immobilized HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer, His & Avi, Human at 0.5μg/ml (100μl/well) on the plate can bind AntiB2M Antibody, mFc Tag. Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

258 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

图例

The purity of HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer, His & Avi, Human on Bis-Tris PAGE under Non reducing (N) condition. The purity is greater than 95%.

技术背景

Target Background	Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target.
Synonyms	Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.

HLA-A*02:01&B2M&Survivin (LMLGEFLKL) Tetramer, His & Avi, Human

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