目录产品 » HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer, His & Avi, Human
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HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer, His & Avi, Human

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
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产品简介
Species Human
Protein Construction
HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer [Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRRC peptide]
Accession # A0A140T913(HLA-A*02:01)&P61769(B2M)&HMTEVVRRC		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer, His & Avi, Human

Immobilized HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer, His & Avi, Human, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 8.1 ng/ml determined by ELISA. »

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer, His & Avi, Human

The purity of HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer, His & Avi, Humanr is greater than 95% as determined by SEC-HPLC. »

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer, His & Avi, Human

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
Synonyms MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.