Immobilized HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His & Avi, Human, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-HLA-A*02:01&B2M&P53 R175H Antibody, hFc Tag with the EC50 of 3.9 ng/ml determined by ELISA.
The purity of HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His & Avi, Human is greater than 95% as determined by SEC-HPLC.
HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His & Avi, Human on Bis-Tris PAGE under Non reducing (N) condition. The purity is greater than 95%.
HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His & Avi, Human
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
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