目录产品 » HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human
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HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
￥3000
Z06585-100

产品简介
Species Human
Protein Construction
HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer[ Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRHC peptide]
Accession # A0A140T913(HLA-A*02:01)&P61769(B2M)& HMTEVVRHC		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Anti-HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Antibody, hFc Tag at 1μg/ml (100μl/well) on the plate can bind Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 51-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS, 100mM L-arginine (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

Immobilized Anti-HLA-A*02:01&B2M&P53 R175H Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human, His Tag with the EC50 of 50.1 ng/ml determined by ELISA. »

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

The purity of HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
Synonyms MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.