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TYRO3, His, Mouse

The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
￥3000 在线订购包邮(港澳台除外)
Z06396-100

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产品简介
Species Mouse
Protein Construction
TYRO3 (Arg31-Asp419)_x000D_
Accession # P55144-2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 43 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
TYRO3, His, Mouse

The purity of TYRO3, His, Mouse is greater than 95% as determined by SEC-HPLC »

TYRO3, His, Mouse

TYRO3, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

TYRO3, His, Mouse

TYRO3, His, Mouse, His Tag immobilized on CM5 Chip can bind Mouse GAS6, His Tag with an affinity constant of 11.31 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
Synonyms BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.