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tPA, His, Mouse

Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism.
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Z06388-100

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产品简介
Species Mouse
Protein Construction
tPA [Ser33-Gln559, which consists of two chains: chain A (Ser33-Arg308) and chain B (Ile309-Gln559)]
Accession # P11214		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its ability to cleave a peptide substrate, N­carbobenzyloxy­Gly­Gly­Arg­7­amido­4­methylcoumarin (ZGGR­AMC). Test result meets the standard.
Expression System HEK293
Theoretical Molecular Weight 60.57 kDa
Apparent Molecular Weight It migrates to 13-15 kDa (chain A and chain B fragment), 30-34 kDa and 35-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
TPA, His, Mouse

tPA, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism.
Synonyms t-PA; tPA; Alteplase; Reteplase; PLAT;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.