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PSMP hFc Chimera, Mouse

PC3-secreted microprotein (PSMP)/microseminoprotein (MSMP) is a novel chemotactic cytokine and its receptor is CCR2. PSMP was highly expressed in fibrotic/cirrhotic tissues from patients with different etiologies of liver disease and in the 3 experimental mouse models of fibrosis. Damage-associated molecular pattern molecules HMGB-1 and IL-33 induced hepatocytes to produce PSMP. PSMP promotes liver fibrosis through inflammatory macrophage infiltration, polarization and production of proinflammatory cytokines, as well as direct activation of hepatic stellate cells via its receptor CCR2.
￥3000 在线订购包邮(港澳台除外)
Z06329-100

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产品简介
Species Mouse
Protein Construction
PSMP (Lys37-Ser139)_x000D_
Accession # B1AWI6		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 37.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 48-51 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
PSMP HFc Chimera, Mouse

The purity of PSMP hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC. »

PSMP HFc Chimera, Mouse

PSMP hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background PC3-secreted microprotein (PSMP)/microseminoprotein (MSMP) is a novel chemotactic cytokine and its receptor is CCR2. PSMP was highly expressed in fibrotic/cirrhotic tissues from patients with different etiologies of liver disease and in the 3 experimental mouse models of fibrosis. Damage-associated molecular pattern molecules HMGB-1 and IL-33 induced hepatocytes to produce PSMP. PSMP promotes liver fibrosis through inflammatory macrophage infiltration, polarization and production of proinflammatory cytokines, as well as direct activation of hepatic stellate cells via its receptor CCR2.
Synonyms Msmp; Psmp; PC3-secreted microprotein
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.