MERTK/Mer, His, Mouse

MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans.

价格	￥3000 在线订购包邮(港澳台除外)
产品编号	Z06266-100
规格	100 μg 500 μg 大单询价
数量
参考货期


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产品简介图例技术背景

产品简介

Species

Mouse

Protein Construction

MERTK/Mer (Gly19-Met497)_x000D_ Accession # Q60805	His
N-term	C-term

Purity

> 95% as determined by BisTris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Expression System

HEK293

Theoretical Molecular Weight

53.38 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 85-105 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

图例

MERTK/Mer, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

The purity of MERTK/Mer, His, Mouse is greater than 95% as determined by SEC-HPLC. »

技术背景

Target Background	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans.
Synonyms	MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.