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IL-12, His, Mouse

Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably.
￥4900
Z06183-100

产品简介
Species Mouse
Protein Construction
IL-12 [Arg23-Ala215(IL-12A)&Met23-Ser335(IL-12B)]
Accession # P43431(IL-12A)&P43432(IL-12B)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK­92 cells. The ED50 for this effect is 0.5 ­ 2 ng/mL. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22.80 kDa(IL-12A)&35.79 kDa(IL-12B)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa(IL-12A)&45-55 kDa(IL-12B) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Interleukin 12 (IL-12) is a pleiotropic cytokine that plays an essential role in Th1-type immune response against cancer, a condition where cells in a particular part of the body grow and reproduce uncontrollably.
Synonyms CLMF; CLMF2; IL-12A; IL-12B; IL12; IL12 p70; IMD28; IMD29; NFSK; NKSF1; NKSF2; P35; IL-12 subunit p35; IL12A; interleukin 12
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.