目录产品 » ICOS/CD278 hFc Chimera, Mouse
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ICOS/CD278 hFc Chimera, Mouse

Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain.
￥3000
Z06166-100

产品简介
Species Mouse
Protein Construction
ICOS/CD278 (Glu21-Leu144)_x000D_
Accession # Q9WVS0		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity ICOS/CD278 hFc Chimera, Mouse captured on CM5 Chip via Protein A can bind Mouse B7­H2, His Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 40.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
ICOS/CD278 HFc Chimera, Mouse

The purity of ICOS/CD278 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC. »

ICOS/CD278 HFc Chimera, Mouse

ICOS/CD278 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

ICOS/CD278 HFc Chimera, Mouse

ICOS/CD278 hFc Chimera, Mouse on CM5 Chip via Protein A can bind Mouse B7-H2, His Tag with an affinity constant of 0.329 μM as determined in SPR assay »

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技术背景
Target Background Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain.
Synonyms AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.