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ALK hFc Chimera, Mouse

Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises.
￥2800 在线订购包邮(港澳台除外)
Z05993-100

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产品简介
Species Mouse
Protein Construction
ALK (Ser19-Cys692)
Accession # P97793		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 101.11 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 115-125 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22μm filtered solution in PBS, 10% Glycerol (pH 7.4).
Concentration Verified by one or more methods from A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises.
Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.