目录产品 » TNFR2/CD120b/TNFRSF1B hFc Chimera, Human
Manual
COAs

TNFR2/CD120b/TNFRSF1B hFc Chimera, Human

Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
￥2600
Z05894-100

产品简介
Species Human
Protein Construction
TNFR2/CD120b/TNFRSF1B (Leu23-Asp257)_x000D_
Accession # P20333-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 51.89 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
返回

图例
TNFR2/CD120b/TNFRSF1B HFc Chimera, Human

Immobilized Human TNF alpha, His Tag at 1 μg/ml(100 μI/well) on the plate. Dose response curve for TNFR2/CD120b/TNFRSF1B hFc Chimera, Human, hFc Tag with the EC50 of 17.1ng/ml determined by ELISA. »

TNFR2/CD120b/TNFRSF1B HFc Chimera, Human

Immobilized TNFR2/CD120b/TNFRSF1B hFc Chimera, Human, hFc Tag at 0.5 μg/ml (100 μI/well) on the plate. Dose response curve for Biotinylated Anti-TNFR2 Antibody, hFc Tag with the EC50 of 19ng/ml determined by ELISA. »

TNFR2/CD120b/TNFRSF1B HFc Chimera, Human

The purity of TNFR2/CD120b/TNFRSF1B hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

TNFR2/CD120b/TNFRSF1B HFc Chimera, Human

TNFR2/CD120b/TNFRSF1B hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

<
>

技术背景
Target Background Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Synonyms CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B
返回

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.