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TGM3/Transglutaminase 3, His, Human

TGM3, encoded by the TGM3 gene, is widely expressed in the small intestine, brain, skin and mucosa. In the skin and mucosa, TGM3 is predominantly expressed in the suprabasal layers of the stratified squamous epithelium. It has been demonstrated that TGM3 is essential for epidermal terminal differentiation and formation of the cornified cell envelope through cross-linking structural proteins such as involucrin, loricrin and small proline-rich proteins.
￥3500
Z05876-100

产品简介
Species Human
Protein Construction
His TGM3/Transglutaminase 3 (Ala2-Glu693)_x000D_
Accession # Q08188
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its ability to cleave a synthetic peptide Benzvloxvcarbonvl­GIn­Glvand NH2OH.Test result meets the standard.
Expression System Baculovirus-Insect Cells
Theoretical Molecular Weight 78.23 kDa
Apparent Molecular Weight The protein has a predicted MW of 78.23 kDa same as Bis-Tris PAGE result.
Formulation Supplied as 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 10% Glycerol (pH 8.5).
Concentration Verified by one or more methods from 0.64mg/ml A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background TGM3, encoded by the TGM3 gene, is widely expressed in the small intestine, brain, skin and mucosa. In the skin and mucosa, TGM3 is predominantly expressed in the suprabasal layers of the stratified squamous epithelium. It has been demonstrated that TGM3 is essential for epidermal terminal differentiation and formation of the cornified cell envelope through cross-linking structural proteins such as involucrin, loricrin and small proline-rich proteins.
Synonyms TG(E); TGE; TGase E; TGase-3; Transglutaminase 3; TGM3
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.