目录产品 » PTP alpha/PTPRA, His, Human
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PTP alpha/PTPRA, His, Human

The receptor protein-tyrosine phosphatase α (encoded by PTPRA), a 130-kDa transmembrane PTP, has shown to be a physiological regulator for PTK c-Src and the kinases involved in integrin signaling pathway including FAK and P130cas. The activation of PTPRA on Src Y530 dephosphorylation led to cellular transformation, which suggested that PTPRA might be an oncogenic gene.
￥3800
Z05779-100

产品简介
Species Human
Protein Construction
PTP alpha/PTPRA (Ala183-Lys802)_x000D_
Accession # P18433-5		 His
N-term C-term
Purity > 90% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System Baculovirus-Insect Cells
Theoretical Molecular Weight 73.00 kDa
Apparent Molecular Weight The protein migrates to 68-75 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 20% glycerol, 3mM DTT (pH 7.4).
Concentration Verified by one or more methods from 0.64mg/ml A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background The receptor protein-tyrosine phosphatase α (encoded by PTPRA), a 130-kDa transmembrane PTP, has shown to be a physiological regulator for PTK c-Src and the kinases involved in integrin signaling pathway including FAK and P130cas. The activation of PTPRA on Src Y530 dephosphorylation led to cellular transformation, which suggested that PTPRA might be an oncogenic gene.
Synonyms R-PTP-alpha; PTPRA; PTPA; PTPRL2; PTP alpha; HEPTP; HLPR; HPTPA;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.