目录产品 » PD-L2/B7-DC hFc Chimera, Human
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PD-L2/B7-DC hFc Chimera, Human

PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
￥2600
Z05745-100

产品简介
Species Human
Protein Construction
PD-L2/B7-DC (Leu20-Thr220)_x000D_
Accession # Q9BQ51		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity PD-L2/B7-DC hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human PD­1, His Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 48.60 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
PD-L2/B7-DC HFc Chimera, Human

The purity of PD-L2/B7-DC hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

PD-L2/B7-DC HFc Chimera, Human

PD-L2/B7-DC hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

PD-L2/B7-DC HFc Chimera, Human

PD-L2/B7-DC hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human PD-1, His Tag with an affinity constant of 0.21 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
Synonyms PDL2; PD-L2; Butyrophilin B7-DC; CD273, PDCD1 ligand 2; PDCD1L2; PDCD1LG2; B7DC; bA574F11.2; Btdc
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.