| ￥2400 | |
| Z05710-100 | |
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| Species | Human | ||||
| Protein Construction |
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| Purity | > 95% as determined by BisTris PAGE | ||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. | ||||
| Expression System | HEK293 | ||||
| Theoretical Molecular Weight | 54.00 kDa | ||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result. | ||||
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). | ||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
Immobilized Human Her4, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for NRG1 Beta 1 hFc Chimera, Human, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA. »
Immobilized Human Her3, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for NRG1 Beta 1 hFc Chimera, Human, hFc Tag with the EC50 of 15.4ng/ml determined by ELISA. »
The purity of NRG1 Beta 1 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »
NRG1 Beta 1 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
| Target Background | Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor. |
| Synonyms | Pro-NRG1; NRG1; GGF; HGL; HRGA; NDF; SMDF; Beta1; Beta1A |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
