目录产品 » M-CSF/CSF-1, His & Avi, Human
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M-CSF/CSF-1, His & Avi, Human

CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of osteoclast progenitors.CSF-1 is cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
￥4900
Z05640-100

产品简介
Species Human
Protein Construction
M-CSF/CSF-1 (Glu33-Asn190)_x000D_
Accession # P09603-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 21.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 28-34 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
M-CSF/CSF-1, His & Avi, Human

Loaded M-CSF/CSF-1, His & Avi, Human, His Tag on Anti-His-Biosensor can bind Human M-CSF R, No Tag with an affinity constant of 0.46 µM as determined in BLI assay (Gator® Prime). »

M-CSF/CSF-1, His & Avi, Human

Measured in a cell proliferation assay using RAW264.7 cells.The ED50 for this effect is 2.5 - 7.0 ng/mL. »

M-CSF/CSF-1, His & Avi, Human

Immobilized M-CSF/CSF-1, His & Avi, Human, His Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Human M-CSF R, hFc Tag with the EC50 of 12.3ng/ml determined by ELISA. »

M-CSF/CSF-1, His & Avi, Human

The purity of M-CSF/CSF-1, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

M-CSF/CSF-1, His & Avi, Human

M-CSF/CSF-1, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »

M-CSF/CSF-1, His & Avi, Human

M-CSF/CSF-1, His & Avi, Human, His Tag captured on CM5 Chip via Anti-his Antibody can bind Human M-CSF R, hFc Tag with an affinity constant of 0.24 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background CSF-1, also known as M-CSF , is a four alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. CSF-1 is also essential for the survival and proliferation of osteoclast progenitors.CSF-1 is cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Synonyms CSF1; CSF-1; MCSF; M-CSF; MGC31930; Lanimostim
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.