目录产品 » LAIR1/CD305 hFc Chimera, Human
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LAIR1/CD305 hFc Chimera, Human

LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
￥3500
Z05558-100

产品简介
Species Human
Protein Construction
LAIR1/CD305 (Gln22-His163)_x000D_
Accession # Q6GTX8-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 42.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
LAIR1/CD305 HFc Chimera, Human

Immobilized LAIR1/CD305 hFc Chimera, Human, hFc Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-LAIR1 Antibody, hFc Tag with the EC50 of 42.6ng/ml determined by ELISA. »

LAIR1/CD305 HFc Chimera, Human

Immobilized Human Collagen I at 2 μg/ml(100 μl/well) on the plate. Dose response curve for LAIR1/CD305 hFc Chimera, Human, hFc Tag with the EC50 of 1.17 μg/ml determined by ELISA. »

LAIR1/CD305 HFc Chimera, Human

The purity of LAIR1/CD305 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

LAIR1/CD305 HFc Chimera, Human

LAIR1/CD305 hFc Chimera, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »

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技术背景
Target Background LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
Synonyms CD305; HLAIR1; LAIR1; LAIR-1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.