目录产品 » Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer, His & Avi, Human
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Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer, His & Avi, Human

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Integrin alpha 5/ beta 1, also known as VLA-5, is a widely expressed non-covalent heterodimer of a 160 kDa alpha 5 and a 130 kDa beta 1 Integrin subunit.Alpha 5/ beta 1 is up‑regulated on tumor vasculature and promotes angiogenesis.
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产品简介
Species Human
Protein Construction
Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer [Phe42-Tyr995(ITGA5) acidic tail and Gln21-Asp728(ITGB1) basic tail]
Accession # P08648(ITGA5)&P05556-1(ITGB1)		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 111.8 kDa (ITGA5) & 83.2 kDa (ITGB1)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 100-140 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Integrin alpha 5/ beta 1, also known as VLA-5, is a widely expressed non-covalent heterodimer of a 160 kDa alpha 5 and a 130 kDa beta 1 Integrin subunit.Alpha 5/ beta 1 is up‑regulated on tumor vasculature and promotes angiogenesis.
Synonyms Integrin alpha 5 beta 1; VLA-5; ITGA5&ITGB1;Integrin alpha 5 β 1; α5β1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.