目录产品 » Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His, Human
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Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His, Human

Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
￥4100
Z05520

产品简介
Species Human
Protein Construction
Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer [Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail]
Accession # P56199-1(ITGA1)&P05556-1(ITGB1)		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 129.1 kDa(ITGA1)&83.2 kDa(ITGB1)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 160-200 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 50mM Tris, 150mM NaCl (pH 7.5).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
Integrin Alpha 1 Beta 1 (ITGA1&ITGB1) Heterodimer, His, Human

Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
Synonyms Integrin alpha 1 beta 1; alpha 1 beta 1; alpha 1; beta 1; ITGA1&ITGB1; ITGA&ITGB;Integrin alpha 1 β 1; alpha 1 β 1; β 1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.