| Species |
Human |
| Protein Construction |
Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer [Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail]
Accession # P56199-1(ITGA1)&P05556-1(ITGB1) |
His |
| N-term |
C-term |
|
| Purity |
> 95% as determined by Bis-Tris PAGE |
| Endotoxin Level |
Less than 1EU per μg by the LAL method. |
| Expression System |
HEK293 |
| Theoretical Molecular Weight |
129.1 kDa(ITGA1)&83.2 kDa(ITGB1) |
| Apparent Molecular Weight |
Due to glycosylation, the protein migrates to 160-200 kDa based on Bis-Tris PAGE result. |
| Formulation |
Lyophilized from 0.22μm filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). |
| Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome. |
| Synonyms |
Integrin alpha 1 beta 1; alpha 1 beta 1; alpha 1; beta 1; ITGA1&ITGB1; ITGA&ITGB;Integrin alpha 1 β 1; alpha 1 β 1; β 1 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
