| ￥3500 | |
| Z05500-100 | |
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| Species | Human | |
| Protein Construction |
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| Purity |
> 95% as determined by BisTris PAGE > 95% as determined by HPLC |
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| Endotoxin Level | Less than 1EU per μg by the LAL method. | |
| Biological Activity | Human IL18BP, hFc Tag captured on CM5 Chip via Protein A can bind IL-37, Human in SPR assay (Biacore T200). Test result was comparable to standard batch. | |
| Expression System | E.coli | |
| Theoretical Molecular Weight | 18.55 kDa | |
| Apparent Molecular Weight | The protein has a predicted MW of 18.55 kDa same as Bis-Tris PAGE result. | |
| Formulation | Lyophilized from 0.22μm filtered solution in 20mM PBS, 2mM DTT (pH 7.4). | |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | |
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
The purity of IL-37, Human is greater than 95% as determined by SEC-HPLC. »
IL-37, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
Human IL-18BP, hFc Tag captured on CM5 Chip via Protein A can bind IL-37, Human, No Tag with an affinity constant of 0.12 μM as determined in SPR assay (Biacore T200). »
| Target Background | IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes. |
| Synonyms | FIL1 zeta; IL-1X; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; FIL1Z; IL1F7; IL1H4; IL1RP1 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
