目录产品 » IL-3 R alpha/CD123, His, Human
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IL-3 R alpha/CD123, His, Human

Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
￥3500
Z05494
现货

产品简介
Species Human
Protein Construction
IL-3 R alpha/CD123 (Thr19-Arg305)
Accession # P26951-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized IL-3 R alpha/CD123, His, Human at 1μg/ml (100μl/Well) on the plate can bind Anti­IL­3 R alpha Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 33.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
IL-3 R Alpha/CD123, His, Human

Immobilized IL-3 R alpha/CD123, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-IL-3 R alpha Antibody, hFc Tag with the EC50 of 7.7 ng/ml determined by ELISA. »

IL-3 R Alpha/CD123, His, Human

The purity of IL-3 R alpha/CD123, His, Human is greater than 95% as determined by SEC-HPLC. »

IL-3 R Alpha/CD123, His, Human

IL-3 R alpha/CD123, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-3 R Alpha/CD123, His, Human

Human IL-3, hFc Tag captured on CM5 Chip via Protein A can bind IL-3 R alpha/CD123, His, Human, His Tag with an affinity constant of 0.276 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
Synonyms CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; MGC34174; IL-3 R alpha
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.