| ￥4900 | |
| Z05480-100 | |
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| Species | Human | ||||||
| Protein Construction |
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| Purity | > 95% as determined by BisTris PAGE | ||||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. | ||||||
| Expression System | HEK293 | ||||||
| Theoretical Molecular Weight | 52.07 kDa (IL-22R alpha 1) and 48.85 kDa (IL-10R beta) | ||||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 68-75 kDa based on Bis-Tris PAGE result. | ||||||
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). | ||||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
Loaded Human IL-22, His Tag on Anti-His-Biosensor can bind IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human, hFc-Avi Tag with an affinity constant of 70.70 nM as determined in BLI assay (Gator® Prime). »
Immobilized Human IL-22, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human, hFc Avi Tag with the EC50 of 0.77 μg/ml determined by ELISA. »
The purity of IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human is greater than 95% as determined by SEC-HPLC. »
IL-22R alpha 1&IL-10R beta hFc Chimera, Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
| Target Background | IL-22Rα1 & IL-10Rβ are receptors for IL-22 and IL-10, mediate the activation of JAK-STAT, MAPK and other signaling pathways, and participate in the process of many inflammatory diseases. IL-22 Rα1 contains cytoplasmic motifs for interactions with signal transduction molecules, but formation of ternary complexes with IL10 Rβ or IL20 Rβ and the respective ligands is required for signal transduction. |
| Synonyms | IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
