目录产品 » Fc epsilon RI alpha/FCER1a, His, Human
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Fc epsilon RI alpha/FCER1a, His, Human

Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. Similarly to the previously investigated beta subunit of the receptor, FCER1A is a good candidate for a quantitative trait locus (QTL) in allergic diseases, and appears to participate in the systemic regulation of IgE levels.
￥2200
Z05273-100

产品简介
Species Human
Protein Construction
Fc epsilon RI alpha/FCER1a (Val26-Gln205)
Accession # P12319-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 48-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
Fc Epsilon RI Alpha/FCER1a, His, Human

Immobilized Fc epsilon RI alpha/FCER1a, His, Human, His Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human IgE, His-Avi Tag with the EC50 of 25.6ng/ml determined by ELISA. »

Fc Epsilon RI Alpha/FCER1a, His, Human

Immobilized Fc epsilon RI alpha/FCER1a, His, Human, His Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-Fc epsilon RI alpha / FCER1a Antibody , hFc Tag with the EC50 of 3.9ng/ml determined by ELISA. »

Fc Epsilon RI Alpha/FCER1a, His, Human

The purity of Fc epsilon RI alpha/FCER1a, His, Human is greater than 95% as determined by SEC-HPLC. »

Fc Epsilon RI Alpha/FCER1a, His, Human

Fc epsilon RI alpha/FCER1a, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. Similarly to the previously investigated beta subunit of the receptor, FCER1A is a good candidate for a quantitative trait locus (QTL) in allergic diseases, and appears to participate in the systemic regulation of IgE levels.
Synonyms Fc-epsilon RI-alpha; FcERI; FCER1A; FCE1A
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.