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CHRDL1, His, Human

CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis.The hypermethylation of the CHRDL1 promoter in gastric cancer, which induced low expression of CHRDL1 and decreased its secretion to the supernatant.
￥3600
Z05168-100

产品简介
Species Human
Protein Construction
His CHRDL1 (Glu28-Cys456)
Accession # Q9BU40-1
N-term C-term
Purity > 90% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CHRDL1, His, Human at 1μg/ml (100μl/Well) on the plate can bind Anti­CHRDL1 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 50 kDa
Apparent Molecular Weight The protein has a predicted MW of 50 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 4mM HCl.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 4mM HCl.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
CHRDL1, His, Human

Immobilized CHRDL1, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-CHRDL1 Antibody, hFc Tag with the EC50 of 6.7 ng/ml determined by ELISA. »

CHRDL1, His, Human

CHRDL1, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 90%. »

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技术背景
Target Background CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis.The hypermethylation of the CHRDL1 promoter in gastric cancer, which induced low expression of CHRDL1 and decreased its secretion to the supernatant.
Synonyms Neuralin-1; Neurogenesin-1; Ventroptin; CHRDL1; NRLN1; CHL; Chordin-like 1; CRDL1; dA141H5.1; VOPT
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.