目录产品 » CEACAM-7, His, Human
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CEACAM-7, His, Human

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell–cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAM7 (CGM2), a member of the CEA family of proteins with expression restricted to the colon and pancreas, as a potential CAR T-cell target for PDAC.
￥3000
Z05165-100

产品简介
Species Human
Protein Construction
CEACAM-7 (Thr36-Ser242)_x000D_
Accession # Q14002-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CEACAM-7, His, Human at 2μg/ml (100μl/well) on the plate can bind Human CEACAM­3, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 24.45 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell–cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAM7 (CGM2), a member of the CEA family of proteins with expression restricted to the colon and pancreas, as a potential CAR T-cell target for PDAC.
Synonyms CGM2; CEACAM7; CEA
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.