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CDH3/Cadherin 3, His, Human

Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.
￥3500
Z05157-100

产品简介
Species Human
Protein Construction
CDH3/Cadherin 3 (Asp108-Gly654)_x000D_
Accession # P22223-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Anti­CDH3 Antibody, hFc Tag at 2μg/ml (100μl/Well) on the plate can bind CDH3/Cadherin 3, His, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 64.32 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
CDH3/Cadherin 3, His, Human

Immobilized Anti-CDH3 Antibody, hFc Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for CDH3/Cadherin 3, His, Human, His Tag with the EC50 of 1.55 mg/ml determined by ELISA. »

CDH3/Cadherin 3, His, Human

CDH3/Cadherin 3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.
Synonyms Cadherin-3;Placental cadherin;P-cadherin;CDH3;CDHP;HJMD;PCAD;PCADP-cadherin;CAD3
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.