目录产品 » CDH17/Cadherin 17 Domain 6-7 mFc Chimera, Human
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CDH17/Cadherin 17 Domain 6-7 mFc Chimera, Human

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
￥4300
Z05151-100

产品简介
Species Human
Protein Construction
CDH17/Cadherin 17 Domain 6-7 (Ser567-Gly777)
Accession # Q12864		 mFc (IgG1)
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 90% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 50.18 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
CDH17/Cadherin 17 Domain 6-7 MFc Chimera, Human

The purity of CDH17/Cadherin 17 Domain 6-7 mFc Chimera, Human is greater than 90% as determined by SEC-HPLC. »

CDH17/Cadherin 17 Domain 6-7 MFc Chimera, Human

CDH17/Cadherin 17 Domain 6-7 mFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Synonyms Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.