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CDH17/Cadherin 17 Domain 1&2, His, Human

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
￥4300
Z05147

产品简介
Species Human
Protein Construction
CDH17/Cadherin 17 Domain 1&2 (Pro30-Pro244)
Accession # Q12864		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CDH17/Cadherin 17 Domain 1&2, His, Human at 1μg/ml (100μl/well) on the plate can bind Anti­CDH17 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.15 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
CDH17/Cadherin 17 Domain 1&2, His, Human

Immobilized CDH17/Cadherin 17 Domain 1&2, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.7 ng/ml determined by ELISA. »

CDH17/Cadherin 17 Domain 1&2, His, Human

CDH17/Cadherin 17 Domain 1&2, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Synonyms Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.