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CDCP1 hFc Chimera, Human

Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.
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Z05143-100

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产品简介
Species Human
Protein Construction
CDCP1 (Phe30-Leu666)
Accession # Q9H5V8-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 98.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 115-130 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
CDCP1 HFc Chimera, Human

Immobilized CDCP1 hFc Chimera, Human, hFc Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-CDCP1 Antibody, hFc Tag with the EC50 of 23.1ng/ml determined by ELISA. »

CDCP1 HFc Chimera, Human

The purity of CDCP1 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

CDCP1 HFc Chimera, Human

CDCP1 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.
Synonyms CDCP1; CD318; SIMA135; TRASK; UNQ2486; PRO5773
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.