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CADM1/IGSF4A, His, Human

The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and has been identified as a tumor suppressor gene. CADM1 has multifunctions on the pathogenesis of malignancies, and other normal cells such as immune cells. On the contrary to these cutaneous solid tumors except for Merkel cell carcinoma, cutaneous lymphomas, such as adult-T cell leukemia/lymphoma, mycosis fungoides, and Sézary syndrome, increase their CADM1 expression for the development of tumor environment.
￥2600
Z05106-100

产品简介
Species Human
Protein Construction
CADM1/IGSF4A (Gln45-His374)
Accession # Q9BY67-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 38 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
CADM1/IGSF4A, His, Human

Immobilized CADM1/IGSF4A, His, Human, His Tag at 0.5 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-CADM1 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA. »

CADM1/IGSF4A, His, Human

The purity of CADM1/IGSF4A, His, Human is greater than 95% as determined by SEC-HPLC. »

CADM1/IGSF4A, His, Human

CADM1/IGSF4A, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and has been identified as a tumor suppressor gene. CADM1 has multifunctions on the pathogenesis of malignancies, and other normal cells such as immune cells. On the contrary to these cutaneous solid tumors except for Merkel cell carcinoma, cutaneous lymphomas, such as adult-T cell leukemia/lymphoma, mycosis fungoides, and Sézary syndrome, increase their CADM1 expression for the development of tumor environment.
Synonyms IgSF4; NECL-2; SgIgSF; SynCAM; TSLC-1; Cadm1; BL2; IGSF4; IGSF4A; RA175; ST17; TSLC1; sTSLC-1; sgIGSF; synCAM1; BL2; NECL2
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.