The purity of B2M/beta 2-Microglobulin, His, Human is greater than 95% as determined by SEC-HPLC.

B2M/beta 2-Microglobulin, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

B2M/beta 2-Microglobulin, His, Human

The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.

产品编号	Z05051
规格	100 μg 500 μg 大单询价
数量
价格	￥2100


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产品简介

Species

Human

Protein Construction

B2M/beta 2-Microglobulin (Ile21-Met119) Accession # P61769-1	His
N-term	C-term

Purity

> 95% as determined by BisTris PAGE
> 95% as determined by HPLC

Endotoxin Level

Less than 1EU per μg by the LAL method.

Expression System

HEK293

Theoretical Molecular Weight

12.8 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 13-15 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

图例

The purity of B2M/beta 2-Microglobulin, His, Human is greater than 95% as determined by SEC-HPLC.

B2M/beta 2-Microglobulin, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

技术背景

Target Background	The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.
Synonyms	Beta-2-microglobulin;B2M;β-2-microglobulin

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.