目录产品 » Azurocidin/CAP37/AZU1/HBP, His, Human
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Azurocidin/CAP37/AZU1/HBP, His, Human

Heparin-binding protein (HBP), also known as cationic antimicrobial protein 37 (CAP37) and Azurocidin, is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3). This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
￥2000
Z05049-100

产品简介
Species Human
Protein Construction
Azurocidin/CAP37/AZU1/HBP (Ile27-Pro250)_x000D_
Accession # P20160		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 25.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22μm filtered solution in 20mM PB,500mM NaCl (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Heparin-binding protein (HBP), also known as cationic antimicrobial protein 37 (CAP37) and Azurocidin, is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3). This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Synonyms CAP37; AZU; AZU1; Azurocidin; HBP; AZAMP; HUMAZUR; NAZC; azurocidin 1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.