| ￥1500 | |
| Z04986-100 | |
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| Species | Human/Cynomolgus | ||||
| Protein Construction |
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| Purity | > 95% as determined by BisTris PAGE | ||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. | ||||
| Expression System | HEK293 | ||||
| Theoretical Molecular Weight | 39.35 kDa | ||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result. | ||||
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). | ||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
Immobilized Human Activin A, No Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Activin RIIA/ACVR2A hFc Chimera, Human/Cynomolgus, hFc Tag with the EC50 of 1.7ng/ml determined by ELISA. »
Immobilized Human/Mouse/Rat GDF-8, No Tag at 2 μg/ml(100 μI/well) on the plate. Dose response curve for Activin RIIA/ACVR2A hFc Chimera, Human/Cynomolgus, hFc Tag with the EC50 of 0.12 μg/ml determined by ELISA. »
The purity of Activin RIIA/ACVR2A hFc Chimera, Human/Cynomolgus is greater than 95% as determined by SEC-HPLC. »
Activin RIIA/ACVR2A hFc Chimera, Human/Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
Activin RIIA/ACVR2A hFc Chimera, Human/Cynomolgus, hFc Tag captured on CM5 Chip via Protein A can bind Human/Mouse/Rat GDF-8, No Tag with an affinity constant of 0.13 nM as determined in SPR assay (Biacore T200). »
| Target Background | Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer. |
| Synonyms | ACTR-IIA; ACTRIIA; ACVR2A; ACVR2 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
