目录产品 » 4-1BB Ligand/TNFSF9 Trimer hFc Chimera, Human
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4-1BB Ligand/TNFSF9 Trimer hFc Chimera, Human

The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.
￥3500
Z04977

产品简介
Species Human
Protein Construction
monomeric hFc 4-1BB Ligand/TNFSF9 Trimer (Arg71-Glu254)
Accession # P41273
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human 4­1BB, His Tag at 1μg/ml (100μl/Well) on the plate can bind 4-1BB Ligand/TNFSF9 Trimer hFc Chimera, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 84.3 kDa
Apparent Molecular Weight The protein has a predicted MW of 84.3 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
4-1BB Ligand/TNFSF9 Trimer HFc Chimera, Human

Immobilized Human 4-1BB, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for 4-1BB Ligand/TNFSF9 Trimer hFc Chimera, Human, hFc Tag with the EC50 of 5.4 ng/ml determined by ELISA. »

4-1BB Ligand/TNFSF9 Trimer HFc Chimera, Human

The purity of 4-1BB Ligand/TNFSF9 Trimer hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

4-1BB Ligand/TNFSF9 Trimer HFc Chimera, Human

4-1BB Ligand/TNFSF9 Trimer hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.
Synonyms 41BB Ligand; 4-1BB Ligand; 4-1BBL; CD137L; TNFSF9
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.