目录产品 » LRRC15/LIB, His, Cynomolgus/Rhesus macaque
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LRRC15/LIB, His, Cynomolgus/Rhesus macaque

The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro.
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Z04952-100

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产品简介
Species Cynomolgus/Rhesus macaque
Protein Construction
LRRC15/LIB (Tyr22-Gly538)
Accession # A0A2K5UKB6 (Cynomolgus) / F7FSB9 (Rhesus macaque)		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 58.92 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
LRRC15/LIB, His, Cynomolgus/Rhesus Macaque

Immobilized Anti-LRRC15 Antibody, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for LRRC15/LIB, His, Cynomolgus/Rhesus macaque, His Tag with the EC50 of 14.2 ng/ml determined by ELISA. »

LRRC15/LIB, His, Cynomolgus/Rhesus Macaque

LRRC15/LIB, His, Cynomolgus/Rhesus macaque on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

LRRC15/LIB, His, Cynomolgus/Rhesus Macaque

The purity of LRRC15/LIB, His, Cynomolgus/Rhesus macaque is greater than 95% as determined by SEC-HPLC. »

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技术背景
Target Background The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro.
Synonyms LIB; LRRC15; EGM_11224
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.