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FcRn, His, Cynomolgus/Rhesus macaque

The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT&B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
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Z04951-100

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产品简介
Species Cynomolgus/Rhesus macaque
Protein Construction
FcRn [Ala24-Ser297 (FCGRT) and Ile21-Met119 (B2M)]
Accession # Q8SPV9 (FCGRT) & Q8SPW0 (B2M)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 31.5 kDa (FCGRT) and 11.6 kDa (B2M)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-38 kDa (FCGRT) and 13-15 kDa (B2M) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
FcRn, His, Cynomolgus/Rhesus Macaque

Immobilized FcRn, His, Cynomolgus/Rhesus macaque, His Tag at 2 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-FcRn Antibody, hFc Tag with the EC50 of 8.6ng/ml determined by ELISA. »

FcRn, His, Cynomolgus/Rhesus Macaque

The purity of FcRn, His, Cynomolgus/Rhesus macaque is greater than 95% as determined by SEC-HPLC. »

FcRn, His, Cynomolgus/Rhesus Macaque

FcRn, His, Cynomolgus/Rhesus macaque on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

FcRn, His, Cynomolgus/Rhesus Macaque

FcRn, His, Cynomolgus/Rhesus macaque, His Tag captured on CM5 Chip via Anti-His Antibody can bind Trastuzumab with an affinity constant of 0.18 μM as determined in SPR assay (Biacore T200). »

FcRn, His, Cynomolgus/Rhesus Macaque

Cynomolgus Serum Albumin, His Tag immobilized on CM5 Chip can bind FcRn, His, Cynomolgus/Rhesus macaque, His Tag with an affinity constant of 0.13 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT&B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Synonyms FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.