目录产品 » IL-3 R alpha/CD123, His, Cynomolgus
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IL-3 R alpha/CD123, His, Cynomolgus

Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
￥3800
Z04840-100

产品简介
Species Cynomolgus
Protein Construction
IL-3 R alpha/CD123 (Arg18-Arg302)
Accession # G8F3K3		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human IL­3, hFc Tag captured on CM5 Chip via Protein A can bind IL-3 R alpha/CD123, His, Cynomolgus in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 33.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
IL-3 R Alpha/CD123, His, Cynomolgus

The purity of IL-3 R alpha/CD123, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

IL-3 R Alpha/CD123, His, Cynomolgus

IL-3 R alpha/CD123, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-3 R Alpha/CD123, His, Cynomolgus

Human IL-3, hFc Tag captured on CM5 Chip via Protein A can bind IL-3 R alpha/CD123, His, Cynomolgus, His Tag with an affinity constant of 0.46 μM as determined in SPR assay (Biacore T200) (QC Test). »

IL-3 R Alpha/CD123, His, Cynomolgus

IL-3 R alpha/CD123, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-3, His Tag with an affinity constant of 1.30 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
Synonyms CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; MGC34174; IL-3 R alpha
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.