| ￥3500 | |
| Z04789-100 | |
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| Species | Cynomolgus | ||||
| Protein Construction |
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| Purity | > 95% as determined by Bis-Tris PAGE | ||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||
| Biological Activity | FcRH5/FcRL5, His, Cynomolgus captured on CM5 Chip via AntiHis Antibody can bind AntiFcRH5 Ab., hFc Tag in SPR assay (Biacore T200). Test result was comparable to standard batch. | ||||
| Expression System | HEK293 | ||||
| Theoretical Molecular Weight | 92.13 kDa | ||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 100-130 kDa based on Bis-Tris PAGE result. | ||||
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). | ||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
FcRH5/FcRL5, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
FcRH5/FcRL5, His, Cynomolgus, His Tag captured on CM5 Chip via Anti-His Antibody can bind Anti-FcRH5 Ab., hFc Tag with an affinity constant of 0.14 μM as determined in SPR assay (Biacore T200). »
Immobilized Anti-FcRH5 Antibody, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for FcRH5/FcRL5, His, Cynomolgus, His Tag with the EC50 of 0.54 μg/ml determined by ELISA. »
| Target Background | FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. |
| Synonyms | FcR-like protein 5; FcRH5; FcRL5; BXMAS1; CD307; CD307e; IFGP5; IRTA2 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
