目录产品 » CTLA-4/CD152, His, Cynomolgus
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CTLA-4/CD152, His, Cynomolgus

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an 'off' switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
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产品简介
Species Cynomolgus
Protein Construction
CTLA-4/CD152 (Ala37-Ser160)
Accession # G7PL88-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 14.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
CTLA-4/CD152, His, Cynomolgus

Immobilized CTLA-4/CD152, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Cynomolgus B7-1, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA. »

CTLA-4/CD152, His, Cynomolgus

Immobilized CTLA-4/CD152, His, Cynomolgus at 1 μg/ml(100 μl/well) on the plate. Dose response curve for Anti-CTLA-4 Antibody, hFc Tag with the EC50 of 14.4ng/ml determined by ELISA. »

CTLA-4/CD152, His, Cynomolgus

The purity of CTLA-4/CD152, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

CTLA-4/CD152, His, Cynomolgus

CTLA-4/CD152, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

CTLA-4/CD152, His, Cynomolgus

Cynomolgus B7-1, His Tag immobilized on CM5 Chip can bind CTLA-4/CD152, His, Cynomolgus, His Tag with an affinity constant of 9.90 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an 'off' switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
Synonyms CTLA4; CD152; ICOS; CELIAC3; GRD4; GSE; ALPS5; IDDM12
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.