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CRTAM, His, Cynomolgus

Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
￥2600
Z04770-100

产品简介
Species Cynomolgus
Protein Construction
CRTAM (Ser18-Gly287)
Accession # XP_005580021.1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CRTAM, His, Cynomolgus at 2μg/ml (100μl/Well) on the plate can bind Anti­CRTAM Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 30.80 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
CRTAM, His, Cynomolgus

Immobilized CRTAM, His, Cynomolgus, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-CRTAM Antibody, hFc Tag with the EC50 of 8.4 ng/ml determined by ELISA. »

CRTAM, His, Cynomolgus

CRTAM, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
Synonyms CD355 antigen; CD355; CRTAM
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.