CDCP1[Biotin], His & Avi, Mouse

Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.

价格	￥5800 在线订购包邮(港澳台除外)
产品编号	Z04652-100
规格	100 μg 500 μg 大单询价
数量
参考货期


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产品简介图例技术背景

产品简介

Species

Mouse

Protein Construction

CDCP1 (Arg25-Ala667) Accession # Q5U462	His	Avi
N-term		C-term

Conjugate

Biotin

Purity

> 95% as determined by BisTris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

AntiCDCP1 Antibody captured on CM5 Chip via Protein A can bind CDCP1[Biotin], His & Avi, Mouse in SPR assay (Biacore T200). Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

75.3 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 80-100 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

图例

The purity of CDCP1[Biotin], His & Avi, Mouse is greater than 95% as determined by SEC-HPLC. »

CDCP1[Biotin], His & Avi, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Anti-CDCP1 Antibody captured on CM5 Chip via Protein A can bind CDCP1[Biotin], His & Avi, Mouse, His Tag with an affinity constant of 0.45 μM as determined in SPR assay (Biacore T200). »

技术背景

Target Background	Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.
Synonyms	CDCP1; CD318; SIMA135; TRASK; UNQ2486; PRO5773

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.