| ￥5800 | |
| Z04594-100 | |
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| Species | Human | ||||||
| Protein Construction |
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| Conjugate | Biotin | ||||||
| Purity | > 95% as determined by BisTris PAGE | ||||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||||
| Biological Activity | Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch. | ||||||
| Expression System | HEK293 | ||||||
| Theoretical Molecular Weight | 100.7 kDa | ||||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 170-200 kDa based on Bis-Tris PAGE result. | ||||||
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). | ||||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
Loaded Anti-SEZ6 Antibody, hFc Tag on ProA-Biosensor can bind SEZ6[Biotin], His & Avi, Human, His-Avi Tag with an affinity constant of 3.31 nM as determined in BLI assay (Gator® Prime). »
Immobilized SEZ6[Biotin], His & Avi, Human, His-Avi Tag at 2 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 9.5ng/ml determined by ELISA. »
The purity of SEZ6[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC. »
SEZ6[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
| Target Background | Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. |
| Synonyms | SEZ-6; SEZ6; BSRPC; BSRP-C |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
