目录产品 » Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer[Biotin], His & Avi, Human
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Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer[Biotin], His & Avi, Human

Integrin ITGAV & ITGB5 is a type of integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. However, it inhibits angiogenesis. It consists of two components, integrin alpha V and integrin beta 5. Integrin ITGAV & ITGB5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.(Microbial infection) Integrin ITGAV & ITGB5 acts as a receptor for adenovirus type C.
￥6600
Z04521-100

产品简介
Species Human
Protein Construction
Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer [Phe31-Val992 (ITGAV) acidic tail & Gly24-Asn719 (ITGB5) basic tail]
Accession # P06756-1 (ITGAV) & P18084 (ITGB5)		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer[Biotin], His & Avi, Human at 1μg/ml (100μl/Well) on streptavidin (5μg/ml) precoated plate can bind Anti­alpha V Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 114 kDa (ITGAV) & 81.4 kDa (ITGB5)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 85-140 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Integrin ITGAV & ITGB5 is a type of integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. However, it inhibits angiogenesis. It consists of two components, integrin alpha V and integrin beta 5. Integrin ITGAV & ITGB5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.(Microbial infection) Integrin ITGAV & ITGB5 acts as a receptor for adenovirus type C.
Synonyms αVβ5; Integrin alpha V beta 5; beta5; alphaV; ITGAV&ITGB5;Integrin alpha V β 5; β5
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.