目录产品 » IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human
Manual
Manual
COAs

IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human

The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.
￥7400 在线订购包邮(港澳台除外)
Z04509-100

咨询产品问题
产品简介
Species Human
Protein Construction
IL-23 alpha & IL-12 beta [Arg20-Pro189 (IL-23 alpha) and Ile23-Ser328 (IL-12 beta)]
Accession # Q9NPF7 (IL-23 alpha) & P29460 (IL-12 beta)		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 21.7 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 24 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
返回

图例
IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human

Immobilized IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human, His Tag at 2 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Human IL-23R, hFc Tag with the EC50 of 19.2 ng/ml determined by ELISA. »

IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human

Immobilized IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human, His Tag at 0.5 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Anti-IL-23 Antibody, hFc Tag with the EC50 of 2.2 ng/ml determined by ELISA. »

IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human

The purity of IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

IL-23 Alpha&IL-12 Beta[Biotin], His & Avi, Human

IL-23 alpha&IL-12 beta[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

<
>

技术背景
Target Background The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.
Synonyms IL23 alpha; IL12 beta; IL23 alpha&IL12 beta ; IL12 β; IL23 alpha&IL12 β; IL-23A&IL-12B; IL23A&IL12B
返回

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.