目录产品 » IL-22R alpha 1&IL-10R beta hFc Chimera[Biotin], Avi, Human

IL-22R alpha 1&IL-10R beta hFc Chimera[Biotin], Avi, Human

IL-22Rα1&IL-10Rβ are receptors for IL-22 and IL-10, mediate the activation of JAK-STAT, MAPK and other signaling pathways, and participate in the process of many inflammatory diseases. IL­-22 Rα1 contains cytoplasmic motifs for interactions with signal transduction molecules, but formation of ternary complexes with IL­10 Rβ or IL­20 Rβ and the respective ligands is required for signal transduction[1].
¥6600
Z04508-100

Species Human
Protein Construction
IL-22R alpha 1 & IL-10R beta [His16-Thr228 (IL-22R alpha 1) and Met20-Ser220 (IL-10R beta)]
Accession # Q8N6P7 (IL-22R alpha 1) & Q08334 (IL-10R beta)
hFc Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human IL­22, His Tag at 5μg/ml (100μl/well) on the plate can bind IL-22R alpha 1&IL-10R beta hFc Chimera[Biotin], Avi, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 52.07 kDa (IL-22R alpha 1) and 48.85 kDa (IL-10R beta)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 68-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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IL-22R Alpha 1&IL-10R Beta HFc Chimera[Biotin], Avi, Human

Immobilized Human IL-22, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for IL-22R alpha 1&IL-10R beta hFc Chimera[Biotin], Avi, Human, hFc Tag with the EC50 of 1.36 μg/ml determined by ELISA. »

IL-22R Alpha 1&IL-10R Beta HFc Chimera[Biotin], Avi, Human

The purity of IL-22R alpha 1&IL-10R beta hFc Chimera[Biotin], Avi, Human is greater than 90% as determined by SEC-HPLC. »

IL-22R Alpha 1&IL-10R Beta HFc Chimera[Biotin], Avi, Human

IL-22R alpha 1&IL-10R beta hFc Chimera[Biotin], Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Target Background IL-22Rα1&IL-10Rβ are receptors for IL-22 and IL-10, mediate the activation of JAK-STAT, MAPK and other signaling pathways, and participate in the process of many inflammatory diseases. IL­-22 Rα1 contains cytoplasmic motifs for interactions with signal transduction molecules, but formation of ternary complexes with IL­10 Rβ or IL­20 Rβ and the respective ligands is required for signal transduction[1].
Synonyms IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.