目录产品 » Siglec-10[Biotin], His & Avi, Cynomolgus
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Siglec-10[Biotin], His & Avi, Cynomolgus

Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.
￥5800
Z04376-100

产品简介
Species Cynomolgus
Protein Construction
Siglec-10[Biotin] (Thr17-Asn552)_x000D_
Accession # A0A2K5WBX8		 His Avi
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 61.71 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 72-82 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22 μm filtered solution in 25mM MES, 150mM NaCl, 0.5M Arginine (pH 5.0).
Concentration Verified by one or more methods from 0.64mg/ml A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.
Synonyms SLG2; SIGLEC10; MGC126774; PRO940
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.