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CD47 hFc Chimera, Rat

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers.
￥2600
Z04353-100

产品简介
Species Rat
Protein Construction
CD47 (Gln19-Lys140)
Accession # P97829-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 40.40 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
CD47 HFc Chimera, Rat

Immobilized Mouse SIRP alpha, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for CD47 hFc Chimera, Rat, hFc Tag with the EC50 of 47.6 ng/ml determined by ELISA. »

CD47 HFc Chimera, Rat

The purity of CD47 hFc Chimera, Rat is greater than 95% as determined by SEC-HPLC. »

CD47 HFc Chimera, Rat

CD47 hFc Chimera, Rat on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers.
Synonyms CD47 glycoprotein; CD47 molecule; CD47; IAP; OA3; MER6
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.