目录产品 » CD40/TNFRSF5 hFc Chimera, Human
Manual
Manual
COAs

CD40/TNFRSF5 hFc Chimera, Human

CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.
￥3000 在线订购包邮(港澳台除外)
Z04206-100

咨询产品问题
产品简介
Species Human
Protein Construction
CD40/TNFRSF5 (Glu21-Arg193)
Accession # P25942-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 45.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
返回

图例
CD40/TNFRSF5 HFc Chimera, Human

CD40/TNFRSF5 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

CD40/TNFRSF5 HFc Chimera, Human

The purity of CD40/TNFRSF5 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

CD40/TNFRSF5 HFc Chimera, Human

Immobilized Human CD40 Ligand (Trimer), His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for CD40/TNFRSF5 hFc Chimera, Human, hFc Tag with the EC50 of 101.8ng/ml determined by ELISA. »

<
>

技术背景
Target Background CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.
Synonyms CD40; CD40L receptor; TNFRSF5; CD40 antigen; CD40 molecule; CDw40; MGC9013;
返回

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.