目录产品 » Siglec-3/CD33[Biotin], His & Avi, Human
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Siglec-3/CD33[Biotin], His & Avi, Human

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state.They are sialoadhesin/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs.
￥5800
Z04101-100

产品简介
Species Human
Protein Construction
Siglec-3/CD33[Biotin] (Asp18-His259)_x000D_
Accession # P20138-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 29.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 48-58 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22μm filtered solution in 50mM MES, 500mM NaCl, 200mM L-arginine (pH 7.4).
Concentration Verified by one or more methods from 0.64mg/ml A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state.They are sialoadhesin/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs.
Synonyms CD33 molecule; CD33; FLJ00391; gp67; Siglec3; Siglec-3; p67
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.